세미나

정보마당세미나

김세윤 교수 세미나 - 2월 23일 (목)
Name : GSMSE | Date : 2012.02.16 11:43 | Views : 14795

2012년도 봄학기 세미나

 

제목: Inositol polyphosphate multikinase signaling in growth and metabolism

 

연자김세윤 교수

 

소속: 카이스트 생명과학과

 

일시: 2012년 2월 23일 목요일, 오후 4

 

장소: 의과학연구센터 강의실 2113

 

Abstract

Inositol is a naturally occurring glucose isomer and a key nutrient of the human diet. When levels of inositol are extremely low, disturbances such as diabetic changes, anxiety disorders, and hypercholesterolemia ensue. Inositol phosphates(IP) as signaling messengers mediate various physiological processes such as growth and apoptosis. IPMK(inositol polyphosphate multikinase) was first identified as Arg82, a transcriptional regulator in yeast. In mammals, IPMK generates inositol tetrakisphosphate(IP4) and IP5 and thus acts upstream of the IP6 kinase. IPMK is also a physiologically important PI3-kinase that forms PIP3 which activates Akt-dependent signaling pathways. IPMK, in a catalytically independent fashion, activates mammalian target of rapamycin(mTOR) in response to essential amino acids. In addition, IPMK regulates glucose signaling to AMP-activated kinase(AMPK) in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine-174 enabling the enzyme to bind to AMPK and regulate its activation. These findings imply that IPMK participates in a network regulating growth factor– and nutrient-mediated signaling.

 

많은 참석 부탁드립니다. ^^

QRcode
%s1 / %s2
 
List Gallery Webzine RSS FEED

No File Subject Name Date Views
공지 jpg GSMSE 2020.09.14 6,156
공지 jpg GSMSE 2020.09.14 5,877
204 blank GSMSE 2012.11.06 10,365
203 blank GSMSE 2012.11.01 9,113
202 blank GSMSE 2012.10.30 10,647
201 blank GSMSE 2012.10.29 9,389
200 blank GSMSE 2012.10.23 9,877
199 blank GSMSE 2012.10.22 9,931
198 blank GSMSE 2012.10.15 9,809
197 blank GSMSE 2012.10.09 9,782
196 blank GSMSE 2012.10.08 9,338
195 blank GSMSE 2012.10.05 9,900
194 blank GSMSE 2012.09.27 11,256
193 blank GSMSE 2012.09.27 9,900
192 blank GSMSE 2012.09.24 9,457
191 blank GSMSE 2012.09.19 10,866
190 blank GSMSE 2012.09.18 11,105
189 blank GSMSE 2012.09.17 12,422
188 blank GSMSE 2012.09.03 10,080
187 blank GSMSE 2012.08.28 10,575
186 blank GSMSE 2012.08.13 13,202
185 blank GSMSE 2012.07.26 11,733