• [Science Immunology] Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron s
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  • 2024-08-28 11:20:46|
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[Title]
Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants

[Author]

Sang- Hoon Kim1†, Jihye Kim1†, Sungmin Jung2†, Ji Yun Noh3†, Jinnam Kim4†, Heedo Park5,Young Goo Song4, Kyong Ran Peck6, Su-Hyung Park2, Man- Seong Park5, Jae- Hoon Ko6*,Joon Young Song3*, Jun Yong Choi4*, Min Kyung Jung1*, Eui- Cheol Shin1,2*

1center for Viral immunology, Korea Virus Research institute, institute for Basic Sci-ence (iBS), Daejeon 34126, Republic of Korea.
2graduate School of medical Scienceand engineering, Korea advanced institute of Science and technology (KaiSt),Daejeon 34141, Republic of Korea.
3Division of infectious Diseases, Department ofinternal medicine, Korea university college of medicine, Seoul 08308, Republic ofKorea.
4Department of internal medicine, yonsei university college of medicine,Seoul 03722, Republic of Korea.
5Department of microbiology, institute for ViralDiseases, Korea university college of medicine, Seoul 02841, Republic of Korea.
6Di-vision of infectious Diseases, Department of medicine, Samsung medical center,Sungkyunkwan university School of medicine, Seoul 06351, Republic of Korea.
†these authors contributed equally to this work.
*corresponding author. email: jaehoon.ko@samsung.com (J.-h.K.); infection@korea.ac. kr (J.y.S.); seran@yuhs.ac (J.y.c.); mkjung@ibs.re.kr (m.K.J.); ecshin@kaist.ac.kr(e.-c.S.)


[Journal] 

Science Immunology, 2024 Jan 19;9(91):eade6132.  doi: 10.1126/sciimmunol.ade6132. Epub 2024 Jan 19.

[Abstract]

Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants.

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