동물모델로 연구하기 어려운 인간의 만성 염증과 자가면역질환을 연구하고자 한다. 분명한 목표를 가진 환자 코호트에 기반하여 최신의 오믹스 연구기법을 통해 염증의 악화와 호전, 그리고 치료에 대한 면역학적 규명이 연구실의 목표이다.

• Clinically driven cohort-based immune profiling of human autoimmune disease

  1.Impact of immunosuppression: Cytokine neutralization on human immune system, Glucocorticoid
  2.Prediction of clinical response and optimization of immune modulation

• Multi-organ and multi-omics profiling of chronic inflammation in animal model and real-world patients

  1.Inflammation atlas using SKG mouse model: Single cell transcriptome and ATAC profiling
  2.Inflammation atlas of SpA: Eye (humor), Spine, Colon, Blood, SF from real-world patients

• Constructing database of hetergenouse response to pathogen and immune suppression

  1.Depicting heterogenous inflammatory response to pathogen including SARS-CoV-2 based on genetic background
  2.Designing strategy to optimize immune suppression in severely-ill patients with hyper-inflammation: Biomarker discovery

• Jeong Seok Lee*,#, June-Young Koh*, Kijong Yi*, Young-Il Kim*, Su-Jin Park, Eun-Ha Kim, Se-Mi Kim, Sung Ho Park, Young Seok Ju, Young Ki Choi#, Su-Hyung Park#. Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Sequential Change of Macrophages During SARS-CoV-2 Infection in Ferrets, Nature Communications (2021)

  12(1):4567

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• Jeong Seok Lee*, Seongwan Park*, Hye Won Jeong*, Jin Young Ahn4*, Seong Jin Choi, Hoyoung Lee, Baekgyu Choi, Su Kyung Nam, Moa Sa, Ji-Soo Kwon, Su Jin Jeong, Heung Kyu Lee, Sung Ho Park, Su-Hyung Park, Jun Yong Choi#, Sung-Han Kim#, Inkyung Jung#, Eui-Cheol Shin# Immunophenotyping of COVID-19 and influenza highlights the role of type I Interferons in development of severe COVID-19. Science Immunology (2020)

  5(49):eabd1554

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• Jeong Seok Lee, Eui-Cheol Shin. The type I interferon response in COVID-19: implications for treatment. Nature Reviews Immunology (2020)

  20(10):585-586.(*co-first author, #co-corresponding author)

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