대사비만당뇨 통합연구실은 에너지대사의 조절에 대한 2가지 큰 주제의 연구를 수행하고 있다.
먼저 베타세포의 성숙과 증식을 조절하는 기전과 Beta Cell Failure의 분자기전을 고유의 마우스모델을 이용하여 연구한다. 두번째 주제는 세로토닌이 말초조직에서 에너지 대사의 조절하는 기전을 마우스모델을 이용하여 규명하고 있다. 특히, 갈색지방과 베이지지방의 활성과 분화를 조절하는 기전, 간과 근육에서 세로토닌이 당대사를 조절하는 과정을 규명하고 있다.
최근에는 Transcriptomics 와 Metabolomics를 활용한 Multiomics 연구방법을 활용하여 마우스와 사람에서 대사질환의 발병기전을 규명하는 연구를 진행하면서 연구결과를 기반으로 지방간, 비만 치료제의 개발을 추진하고 있다.

Diabetes affects more than 8% of the population. The Metabolic Disease Research Lab aims to cure diabetes. In an attempt to find ways to cure diabetes, we are focusing on the two most important cells, hepatocytes and pancreas beta cells which are the first line defense to maintain normal blood glucose levels. The scientific identity of this lab is molecular physiology. We take advantage of molecular biology and mouse genetics as research tools. We are actively collaborating with researchers in the different areas. We are open to anyone who wants to cure diabetes or who can help us to cure diabetes.

• Regulation of differentiation and proliferation of hepatocytes and beta-cells
• Regulation of glucose metabolism in hepatocytes and beta-cells
• Tissue specific regulation of gene expression in hepatocytes and beta-cells
• Reconstitution of pancreatic islets in vitro

• Joon Ho Moon, Hyeongseok Kim, Hyunki Kim, Jungsun Park, Wonsuk Choi, Wongun Choi, Hyun Jung Hong, Hyun-Joo Ro, Sangmi Jun, Sung Hee Choi, Ronadip R. Banerjee, Minho Shong, Nam Han Cho, Seung K. Kim, Michael S. German, Hak Chul Jang#, Hail Kim#. Lactation improves pancreatic β cell mass and function through serotonin production. Sci. Transl. Med. (2020)

  12, eaay0455 (#corresponding authors)

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• Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwang Kim, Vijay K. Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Young Park, Sangkyu Park & Hail Kim. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nat Commun (2018)

  16;9(1):4824

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• Chang-Myung Oh, Jun Namkung Younghoon Go, Ko Eun Shong, Kyuho Kim, Hyeongseok Kim, Bo-Yoon Park, Ho Won Lee, Yong Hyun Jeon, Junghan Song, Minho Shong, Vijay K. Yadav, Gerard Karsenty Shingo Kajimura, In-Kyu Lee, Sangkyu Park and Hail Kim. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun. (2015)

  13;6:6794

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