중개면역 및 백신 연구실(Laboratory of Translational Immunology & Vaccinology)에서는 암, 난치성 감염질환, 자가면역질환 등의 다양한 면역관련 질병을 대상으로, (1) 암환자의 종양 미세환경 내의 탈진화 세포와 면역 세포들의 특성 및 항종양 면역반응의 기전 연구, (2) 신/변종 바이러스 감염 질환에 대한 방어면역 특성 규명 및 백신 치료제 개발 연구, (3) 간질환(간암, 만성간염, 알콜성간질환, 간이식)의 병리 및 치료에 관여하는 면역기전 연구 등 다양한 중개면역 연구를 수행 중이다.
특히, 대학병원의 임상연구진과의 공동연구를 활발히 수행 중이며, 환자의 임상샘플을 이용한 중개면역 연구와 질병동물모델을 이용한 세포 및 분자 수준의 기전 규명 연구 유세포분석 및 첨단 면역학 연구기법을 통하여 함께 수행 중에 있다.

Lab. of Translational Immunology & Vaccinology studies (1) Protective T cell immunity against intractable infectious diseases, (2) Detailed immunological mechanisms involved in pathogenesis and prognosis of infectious and immunologic diseases, (3) Novel immunological biomarkers for prognosis of infectious and immunologic diseases. To this end, we are conducting sophisticated techniques in translational immunology using patients’ clinical samples. In parallel, based on multidisciplinary studies in translational and basic immunology, we focus on the development of novel T cell-based preventive and therapeutic vaccines to intractable infectious diseases.

• Hyung-Don Kim, Seongyeol Park, Seongju Jeong, YongJoon Lee, Hoyoung Lee, Chang Gon Kim, Kyung Hwan Kim, Seung-Mo Hong, Jung-Yun Lee, Sunghoon Kim, Hong Kwan Kim, Byung Soh Min, Jong Hee Chang, Young Seok Ju, Eui-Cheol Shin, Gi-Won Song, Whin Hwang, and Su-Hyung Park. 4-1BB delineates distinct activation status of exhausted tumor-infiltrating CD8+ T cells in hepatocellular carcinoma. Hepatology (2020)

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• Jeong-Eun Kwak, Young-Il Kim, Su-Jin Park, Min-Ah Yu, Hyeok-Il Kwon, Sukyeong Eo, Tae-Shin Kim, Joon Seok, Won-Suk Choi, Ju Hwan Jeong, Hyojin Lee, Youngran Cho, Jin Ah Kwon, Moonsup Jeong, Joel N. Maslow, Yong-Eun Kim, Haili Jeon, Kee K. Kim, Eui-Cheol Shin, Min-Suk Song, Jae U. Jung, Young Ki Choi and Su-Hyung Park. Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets. Nature Communications (2019)

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• Hyung-Don Kim, Gi-Won Song, Seongyeol Park, Min Kyung Jung, Min Hwan Kim, Hyo Jeong Kang, Changhoon Yoo, Kijong Yi, Kyung Kwan Kim, Sukyeong Eo, Deok-Bog Moon, Seung-Mo Hong, Young Seok Ju, Eui-Cheol Shin, Shin Hwang, and Su-Hyung Park. Association between expression level of PD1 by tumor-infiltrating CD8 T cells and features of hepatocellular carcinoma. Gastroenterology (2018)

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