김준

Ph.D.

분자유전학, 세포생물학

  • 042-350-4242 (lab. 042-350-4282)
  • joonkim@kaist.ac.kr
  • 질병기능유전체학 연구실
LAB WEBSITE
  • 연구분야
    • 본 실험실에서는 차세대 표적 항암제 개발을 최종 목표로 한 암세포 핵막 불안정성 및 항암제 저항성 유도 전사 프로그램을 연구하고 있다. 

      1. Mechanisms of maintaining morphological homeostasis and membrane integrity of the normal cell nuclear envelope
      2. Mechanisms of inducing morphological abnormalities and membrane instability of the nuclear and micronuclear membrane
         of cancer cells
      3. Effects of perturbation of nuclear membrane integrity of cancer cells on genome instability and cancer microenvironment
      4. Control of the drug resistance-promoting transcription program centered on YAP

  • Major
    Publications
    • Kim YJ, Jung E, Shin E, Hong SH, Jeong HS, Hur G, Jeong HY, Lee SH, Lee JE, Kim GW, and Kim J. Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation. PNAS (2020)

      117:19994-20003

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    • Kim YJ, Kim S, Jung Y, Jung E, Kwon HJ, and Kim J. Eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes. J Clin Invest (2018)

      128:3642-3648

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    • Kim MH, Kim J, Hong H, Lee SH, Lee JK, Jung E, and Kim J. Actin Remodeling Confers BRAF Inhibitor Resistance to Melanoma Cells through YAP/TAZ Activation. EMBO J (2016)

      35:462-478

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  • 연구실 소개
    질병기능유전체학 실험실